COMET is a tool for selection of marker panels from single-cell RNA-seq data. COMET leverages the minimal Hypergeometric test to rank single- and multiple-gene marker panels for their ability to isolate predefined cell populations (clusters) using single-cell RNA-seq data.

COMET is available via this web interface as well as a downloadable package which enables extended flexibility (see documentation link above). COMET is a young tool, and we welcome any input!

The paper describing COMET is now in press at Molecular Systems Biology and can be viewed on bioRxiv here!